Scientists are currently working on a pill which will effectively prevent males from having children for up to two years. The compound is 99 percent successful in preventing reproduction in mice.
To prevent pregnancy, men take the contraceptive pill. This pill targets a protein in the body called the retinoic acid receptor alpha, or RAR-α, which plays a role in cell growth and sperm formation. Researchers examined this protein and designed chemicals that would effectively shut it down in cells.
The study found that the chemical, YCT529, was able to prevent sperm production in the males of the mouse. When it was tested against the sperm cells of mice, it proved to be 100 percent effective without any side effects.
The scientists discovered that female mice were able to get pregnant again and bear a litter of young within four to six weeks of stopping exposure to the toxic chemicals.
Gunda Georg, who is the head of the Department of Medicinal Chemistry at the University of Minnesota, which was involved in the work, says that human clinical trials will start in the third or fourth quarter of this year.
The search for a male birth control pill has been going on for decades but none have been made available. For now, men have only two options when it comes to contraception: condoms or vasectomy (a surgical procedure).
There are a number of different types of contraceptives being investigated. One type of hormonal male contraceptive pill is 11-beta-methyl-19-nortestosterone dodecylcarbonate, which works by reducing levels of hormones required for sperm production.
The results of a Phase I trial of the pill, which was led by researchers at the University of Washington School of Medicine along with UCLA, found that the subjects given the pill experienced drops in levels of two hormones associated with sperm production with mild side effects reported including fatigue, acne and headache, according to ClinicalTrials.gov.
When we first saw the ruling from the Supreme Court last week that the contraception drug ella may be available without a prescription over the counter, we immediately thought, “We have to get this out there!
A new form of birth control that works by blocking the action of testosterone in the body has been successfully tested in a small group of men.
Hormonal pills are the most popular contraceptives for women. They can come with many side effects including weight gain, headaches, sore breasts, irregular periods, mood changes and reduced sexual desire.
In addition to using hormonal birth control, some people also take a form of birth control called intrauterine devices. Contraline is developing a gel-based birth control method that is injected directly into the vas deferens.
You’ll love the gel designed to block sperm from traveling through this tube. Eventually the gel liquifies and the barrier to sperm flow is removed.
A team of scientists has made headlines after stating that an in-development male birth control compound has been 99 percent effective in animal tests.
The male contraceptive, which can be taken orally, targets a protein in the body called the retinoic acid receptor alpha, or RAR-α, which plays a part in cell growth and sperm formation.
Researchers examined this protein and designed chemical compounds that would effectively shut it off in cells. They found that one compound in particular, called YCT529, was effective at doing so.
When given to male mice for four weeks, it reduced sperm counts and was 99 percent effective in preventing pregnancy without any observable side effects, according to a press release from the American Chemical Society (ACS). The mice were able to father babies again within four to six weeks after they stopped taking the chemical.
Their findings were outlined at the ACS Spring 2022 meeting held from March 20th to the 24th.
According to Gunda Georg, head of the Department of Medicinal Chemistry at the University of Minnesota, who was involved in the work, human clinical trials are set to begin in the third or fourth quarter of this year.
The search for a male birth control pill has been going on for decades but none have been made available yet. At the moment, the two contraceptive methods available to men are condoms and vasectomy—the latter being a surgical procedure.
A number of other methods are being investigated. One type of hormonal male birth control pill, 11-beta-methyl-19-nortestosterone dodecylcarbonate, works by reducing levels of hormones required for sperm production.
A Phase I trial of the pill, led by researchers at the University of Washington School of Medicine along with UCLA a few years ago, found that subjects given the pill experienced drops in levels of two hormones associated with sperm production with mild side effects reported including fatigue, acne and headache, according to Clinical Trials Arena. The effects were reversible after stopping treatment.
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Another type of pill called DMA undecanoate, which also works by suppressing male hormones to decrease production of sperm, is also under investigation.
Hormonal pills are a popular contraceptive method among women but they can come with side effects including weight gain, headaches, sore breasts, irregular periods, mood changes and decreased sexual desire, according to the American Academy of Family Physicians.
There are other potential methods for men that do not involve pills. ADAM is a birth control method being investigated by medical device company Contraline. It would work by injecting a gel into the vas deferens—a tube that transports sperm to the penis in preparation for ejaculation.
The gel is designed to block sperm from traveling through this tube. Eventually the gel liquifies and the barrier to sperm flow is removed.
